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Sequence analysis of mitochondria DNA from a large Chinese family of aminoglycoside-induced hearing loss revealed the C1494T mutation in the 12S rRNA gene (Zhao et al., Complete mitochondrial genome sequence analysis of individuals revealed that aminoglycoside drug sensitivity was associated with several other mitochondrial DNA mutations

Flavonoids are also associated with plant growth and development and play a role in the growth of plant leaves through their antioxidant capacity and regulatory properties [11]

In very difficult HS cases, the oral steroid (prednisone) can be added on a short term basis while other therapies begin to work more completely